The Drive
Health, Fitness & Longevity
About
Dr. Peter Attia's deep dive into longevity, performance and health.
Episodes
- #390 ‒ AMA #84: Family health history, preventing heart disease, metabolic health, strength training efficiency, dementia risk reduction, NAD supplements, and hydration
In this AMA episode, Peter Attia addresses listener questions on diverse health topics. He covers family health history, heart disease prevention, metabolic health, effective strength training, and dementia risk reduction, as well as NAD s…
- #389 - Thinking scientifically: why it's hard, why it matters, and a practical toolkit
This episode explores scientific thinking, including why it is difficult for humans, the cognitive biases that make it challenging to separate belief from evidence, and why these challenges are consequential in an environment with misinfor…
- #388 — Prostate cancer screening: why current PSA guidelines are failing men and how modern tools improve early detection and save lives
This episode of The Drive examines prostate cancer screening. It discusses challenges with current PSA guidelines, the role of modern screening tools, and strategies for early detection and treatment of aggressive cancers.
- #387 - AMA #83: Peptides—evaluating the science, safety, and hype in a rapidly growing field
In this AMA episode, Peter Attia discusses peptides, covering their evaluation, the differences between FDA-approved and gray-market options, and their potential future in medicine. He provides a framework for understanding peptide mechani…
- #386 - Aging clocks—what they measure, how they work, and their clinical and real-world relevance
This episode explores the science and application of aging clocks, including what they are, how they measure biological and chronological age, and their clinical relevance. It also discusses key research in the field and the limitations of…
- #385 - AMA #82: Applying the tools of longevity in the real world: disease prevention, DEXA scans, artificial sweeteners, injury recovery, stability training, habit formation, protein intake and mTOR activation, and more
In this AMA episode, Peter Attia addresses listener questions on applying longevity tools in real-world scenarios. He discusses topics such as disease prevention strategies, the utility of DEXA scans, artificial sweeteners, injury recovery…
- #384 - Special episode — Obicetrapib: The CETP inhibitor with cardiovascular benefits and potential Alzheimer's prevention
This episode discusses obicetrapib, an investigational drug that acts as a CETP inhibitor. It covers the history of CETP inhibitors, their effects on cardiovascular risk factors, and potential implications for Alzheimer's disease based on…
- #380 ‒ The seed oil debate: are they uniquely harmful relative to other dietary fats? | Layne Norton, Ph.D.
Layne Norton, Ph.D. discusses the seed oil debate, presenting an evidence-based case against their unique harm. Peter Attia argues the opposing view, exploring scientific bias, historical trials, and mechanistic biology related to cardiome…
- #379 - AMA #79: A guide to cardiorespiratory training at any fitness level to improve healthspan, lifespan, and long-term independence
This episode of The Drive focuses on cardiorespiratory training. It provides a guide to structuring training for healthspan, lifespan, and long-term independence, covering topics such as zone 2 training, VO₂ max, and balancing training int…
- #378 ‒ Women's health and performance: how training, nutrition, and hormones interact across life stages | Abbie Smith-Ryan, Ph.D.
In this episode, Dr. Abbie Smith-Ryan explores women's health and performance, focusing on how training, nutrition, and hormones interact across various life stages. She discusses topics such as early exercise for girls, training and nutri…
- Building & Changing Habits | James Clear (#183 rebroadcast)
This episode features James Clear, author of "Atomic Habits," who discusses habit formation and behavior change. He explains his "Four Laws of Behavioral Change" and provides insights into creating and breaking habits.
- #377 ‒ Special episode: Understanding true happiness and the tools to cultivate a meaningful life—insights from past interviews with Arthur Brooks
This episode of The Drive features a discussion with author Arthur Brooks about happiness. The conversation covers themes such as understanding happiness, factors that undermine it, and practices for cultivating a meaningful life.
- #376 - AMA #78: Longevity interventions, exercise, diagnostic screening, and managing high apoB, hypertension, metabolic health, and more
In this AMA episode, Peter Attia addresses listener questions on lifespan interventions, exercise, cardiovascular risk reduction, and metabolic health. He discusses strategies for extending healthspan and lifespan, managing high apoB and b…
- #375 - Ketogenic diet, ketosis & hyperbaric oxygen: metabolic therapies for weight loss, cognition, Alzheimer's & more | Dom D'Agostino, Ph.D.
Dom D'Agostino, Ph.D. discusses ketogenic diets, ketosis, and hyperbaric oxygen. He explains how a ketogenic diet can support metabolic health and weight loss, and surveys the landscape of exogenous ketones. The conversation also covers hy…
- #374 - The evolutionary biology of testosterone: how it shapes male development and sex-based behavioral differences, | Carole Hooven, Ph.D.
Carole Hooven, Ph.D. explores how prenatal testosterone influences male development and behavior, including aggression. She discusses sex differences, hormonal impacts across the lifespan, and the implications of biological sex differences.
- The impact of gratitude, serving others, embracing mortality, and living intentionally | Walter Green (#288 rebroadcast)
Walter Green, author and founder of the "Say It Now" movement, discusses embracing mortality, living intentionally, and serving others. He shares insights from his upbringing and the importance of expressing gratitude to loved ones.
- #373 – Thyroid function and hypothyroidism: why current diagnosis and treatment fall short for many, and how new approaches are transforming care | Antonio Bianco, M.D., Ph.D.
This episode features Antonio Bianco discussing thyroid function and hypothyroidism. He covers thyroid hormone production, conversion, and regulation, as well as the shortcomings of current diagnostic and treatment approaches.
- #372 - AMA #77: Dietary fiber and health outcomes: real benefits, overhyped claims, and practical applications
In this episode, Peter Attia discusses the science of dietary fiber. He examines its effects on digestion, satiety, weight management, and glycemic control, as well as its role in lipid metabolism, cardiovascular risk, and colorectal cance…
- #371 – Women's sexual health: desire, arousal, and orgasms, navigating perimenopause, and enhancing satisfaction | Sally Greenwald, M.D., M.P.H.
In this episode, Sally Greenwald, M.D., M.P.H., discusses women's sexual health from a hormonal and physiologic perspective. She covers topics such as desire, arousal, pelvic floor function, contraception, menopause care, and strategies fo…
- Longevity 101: a foundational guide to Peter's frameworks for longevity, and understanding CVD, cancer, neurodegenerative disease, nutrition, exercise, sleep, and more (re-broadcast)
This episode provides a comprehensive introduction to longevity, covering Peter Attia's frameworks for lifespan, healthspan, and the prevention of major diseases. It details five key strategies for improving longevity.
- #370 - AMA #76: Peter evaluates longevity drugs, aspirin for CVD, and strategies to improve muscle mass — proven, promising, fuzzy, noise, or nonsense?
Peter revisits the "proven, promising, fuzzy, noise, nonsense" scale, applying it to longevity drugs (GLP-1 receptor agonists, SGLT2 inhibitors, methylene blue, telomere-lengthening supplements), low-dose aspirin for cardiovascular disease…
- #369 ‒ Rethinking protein needs for performance, muscle preservation, and longevity, and the mental and physical benefits of creatine supplementation and sauna use | Rhonda Patrick, Ph.D.
Rhonda Patrick, Ph.D., joins Peter to discuss protein requirements for muscle, performance, and aging. The conversation also covers creatine supplementation and the benefits of sauna use.
- #368 ‒ The protein debate: optimal intake, limitations of the RDA, whether high-protein intake is harmful, and how to think about processed foods | David Allison, Ph.D.
In this episode of The Drive, David Allison, Ph.D. discusses protein intake, including the RDA, potential harms of high-protein diets, and the challenges of nutrition studies. He also addresses processed foods and public health challenges…
- #367 - Tylenol, pregnancy, and autism: What recent studies show and how to interpret the data
This episode of The Drive examines recent studies linking acetaminophen (Tylenol) use during pregnancy to autism. Peter Attia provides a framework for critically evaluating complex conditions and related research, emphasizing the importanc…
- #366 ‒ Transforming education with AI and an individualized, mastery-based education model | Joe Liemandt
Joe Liemandt, an entrepreneur turned education reformer, discusses transforming K-12 education with an individualized, mastery-based model that leverages AI. He details the shortcomings of traditional education and how Alpha School utilize…
- #365 ‒ Training for longevity: A roundtable on building strength, preventing injury, meeting protein needs, guidance for women and youth athletes, and more | Gabrielle Lyon, Mike Boyle, Jeff Cavaliere
This episode of The Drive features a roundtable with Gabrielle Lyon, Mike Boyle, and Jeff Cavaliere on training for longevity. They discuss resistance training, muscle mass, injury prevention, protein intake, and considerations for women a…
- #364 – AMA #75: Diets: how to evaluate and implement any diet including keto, carnivore, vegan, Mediterranean, and more
In this Ask Me Anything episode, Peter Attia discusses evaluating various diets like keto, carnivore, vegan, and Mediterranean. He outlines five non-negotiable criteria for sustainable eating patterns and provides a framework for assessing…
- #363 ‒ A new frontier in neurosurgery: restoring brain function with brain-computer interfaces, advancing glioblastoma care, and new hope for devastating brain diseases | Edward Chang, M.D.
In this episode, Dr. Edward Chang discusses the evolution of neurosurgery, strategies for improving outcomes in glioblastoma, and breakthroughs in brain-computer interfaces. He also shares his vision for future treatments for devastating b…
- Lower back pain: causes, treatment, and prevention of lower back injuries and pain | Stuart McGill, Ph.D. (#287 rebroadcast)
Dr. Stuart McGill explores lower back pain, covering anatomy, spinal function, and injury prevention. He discusses treatment approaches, emphasizing individualized exercises and the importance of strength and stability for a healthy spine.
- #361 - AMA #74: Sugar and sugar substitutes: weight control, metabolic effects, and health trade-offs
In this AMA episode, Peter evaluates sugar and its substitutes in the context of health. He discusses their effects on weight control, metabolic health, and overall health, covering natural vs. refined sugars and various popular sweeteners.
- #360 ‒ How to change your habits: why they form and how to build or break them | Charles Duhigg, M.B.A
Charles Duhigg, a Pulitzer Prize-winning journalist and author, discusses the neuroscience of habit formation, focusing on how habits are formed and how to build or break them. He explores the role of cue-routine-reward loops, the effectiv…
- #359 ‒ How metabolic and immune system dysfunction drive the aging process, the role of NAD, promising interventions, aging clocks, and more | Eric Verdin, M.D.
Dr. Eric Verdin, CEO of the Buck Institute for Research on Aging, discusses how epigenetics, metabolism, and the immune system influence the aging process. He explores the impact of impaired immune and nervous system function, metabolic un…
- #358 ‒ Peter's takeaways on navigating HRT, rejuvenating the face, understanding the biology of aging, optimizing fertility, and learning to live well from the dying | Quarterly Podcast Summary #6
This episode is a quarterly summary where Peter Attia discusses his biggest takeaways from recent guest interviews. He covers insights on male and female fertility, women's sexual health and hormone replacement therapy, the biology of agin…
- #357 ‒ A new era of longevity science: models of aging, human trials of rapamycin, biological clocks, promising compounds, and lifestyle interventions | Brian Kennedy, Ph.D.
Brian Kennedy, Ph.D., discusses ongoing human aging studies, including clinical trials of rapamycin and the development of a more actionable biological clock. He also covers the potential of compounds like alpha-ketoglutarate, urolithin A,…
- #356 - AMA #73: Preserving brain health, optimizing exercise programming, improving body composition, and more
In this "Ask Me Anything" (AMA) episode, Peter addresses frequently requested topics, including brain health, exercise programming, and body composition. He explores factors influencing dementia risk, explains how to implement zone 2 train…
- Navigating bone health: early life influences and advanced strategies for improvement and injury prevention (#214 rebroadcast)
This episode discusses bone health, covering bone mineral density, its measurement, and how it changes across the lifespan. It also explores strategies for improving bone health through exercise, nutrition, and supplements, as well as mini…
- #355 – Skincare strategies, the science of facial aging, and cosmetic-intervention guidance | Tanuj Nakra, M.D. & Suzan Obagi, M.D.
Drs. Tanuj Nakra and Suzan Obagi discuss the science of facial aging, skin health, and cosmetic interventions. They examine the biological and hormonal drivers of facial aging, the impact of modern media on beauty standards, and ethical co…
- #354 – What the dying can teach us about living well: lessons on life and reflections on mortality | BJ Miller, M.D. and Bridget Sumser, L.C.S.W.
In this episode, Drs. BJ Miller and Bridget Sumser share insights from their work in end-of-life care. They discuss the emotional and physiological processes of dying, cultural barriers to discussing death, and how engaging with mortality…
- #353 - AMA #72: Fasting: benefits for body composition and disease prevention, potential risks, and Peter's updated practical framework
This episode of The Drive explores fasting, discussing its terminology, types, and potential benefits for body composition, metabolic health, and disease prevention. It also examines the risks associated with fasting and offers a practical…
- #352 ‒ Female fertility: optimizing reproductive health, diagnosing and treating infertility and PCOS, and understanding the IVF process | Paula Amato, M.D.
This episode, featuring Dr. Paula Amato, explores female fertility, including hormonal changes, the menstrual cycle, ovulation, and the impact of age and lifestyle on fertility. It also covers treatment options for conditions like PCOS and…
- #351 ‒ Male fertility: optimizing reproductive health, diagnosing and treating infertility, and navigating testosterone replacement therapy | Paul Turek, M.D.
This episode of The Drive podcast features Dr. Paul Turek, an expert in male fertility and reproductive health. He discusses optimizing reproductive health, diagnosing and treating infertility, and understanding testosterone replacement th…
- #350 ‒ Injury prevention, recovery, and performance optimization for every decade | Kyler Brown, D.C.
Kyler Brown, D.C., a sports rehab chiropractor, discusses injury prevention, recovery, and performance optimization. He shares his approach to assessing and treating individuals, understanding movement dynamics, and personalized rehab stra…
- #349 - AMA #71: Building strength and muscle mass: how to optimize training, nutrition, and more for longevity
This episode of The Drive focuses on the importance of muscle mass and strength for longevity, metabolic health, and injury prevention. Peter Attia discusses strategies for building muscle safely and effectively, including training, nutrit…
- #348 ‒ Women's sexual health, menopause, and hormone replacement therapy (HRT) | Rachel Rubin, M.D.
In this episode, Dr. Rachel Rubin discusses women's sexual health, menopause, and hormone replacement therapy. She covers hormonal changes, associated health risks, and the historical context and controversies surrounding HRT.
- #347 – Peter's takeaways on mastering sleep, dealing with chronic pain, developing breakthrough cancer drugs, transforming healthcare with AI, advancing radiation therapy, and healing trauma | Quarterly Podcast Summary #5
This episode features Peter Attia summarizing discussions from recent guest interviews. Topics include mastering sleep, understanding chronic pain, developing cancer drugs, using AI in healthcare, advances in radiation therapy, and healing…
- #346 - Scaling biotech and improving global health: lessons from an extraordinary career in medicine | Susan Desmond-Hellmann, M.D., M.P.H.
Susan Desmond-Hellmann, M.D., M.P.H., shares insights from her career spanning clinical medicine, oncology, biotech innovation, and global health leadership. She discusses her experiences developing cancer therapies, and her leadership rol…
- #345 ‒ Chronic pain: pathways, treatment, and the path to physical and psychological recovery | Sean Mackey, M.D., Ph.D.
Dr. Sean Mackey, a professor of pain medicine at Stanford University, joins Peter to discuss chronic pain. They cover pain transmission, types of pain, individual perception differences, and management strategies, including medication and…
- #344 - AMA #70: Nicotine: impact on cognitive function, performance, and mood, health risks, delivery modalities, and smoking cessation strategies
This episode explores nicotine, differentiating it from tobacco and discussing its effects on health, cognitive function, and physical performance. It also covers various nicotine delivery methods and strategies for smoking cessation.
- #343 – The evolving role of radiation: advancements in cancer treatment, emerging low-dose treatments for arthritis, tendonitis, and injuries, and addressing misconceptions | Sanjay Mehta, M.D.
Dr. Sanjay Mehta, a radiation oncologist, discusses the evolving field of radiation oncology. He covers advancements in cancer treatment, emerging low-dose radiation therapies for inflammatory conditions, and addresses common misconception…
- #342 ‒ Aging well: Peter shares strategies for improving longevity with residents at a senior living center
In this episode, Peter Attia shares strategies for longevity, covering exercise, nutrition, sleep optimization, brain health, and emotional well-being with residents at a senior living center. He emphasizes the importance of strength train…