No Priors: Artificial Intelligence | Technology | Startups
Technology
About
At this moment of inflection in technology, co-hosts Elad Gil and Sarah Guo talk to the world's leading AI engineers, researchers and founders about the biggest questions: How far away is AGI? What markets are at risk for disruption? How will commerce, culture, and society change? What’s happening in state-of-the-art in research? “No Priors” is your guide to the AI revolution. Email feedback to show@no-priors.com.Sarah Guo is a startup investor and the founder of Conviction, an investment firm purpose-built to serve intelligent software, or "Software 3.0" companies. She spent nearly a decade incubating and investing at venture firm G...
Episodes
- Baseten CEO Tuhin Srivastava on the AI Inference Crunch, Custom Models, and Building the Inference Cloud
Baseten CEO Tuhin Srivastava joins Sarah Guo and Elad Gil to discuss the growth of AI inference, custom models, and GPU capacity. He explains why the application layer is important and covers Baseten's multi-cloud fabric and operational le…
- SAP: Bringing the ‘Operating System’ of a Company into the AI Era with CTO Philipp Herzig
SAP CTO Philipp Herzig joins Sarah Guo to discuss how SAP is bringing its enterprise software into the AI era. He explains SAP's approach to AI adoption for its customers, focusing on customer outcomes, user interface changes, business pro…
- Scaling Global Organizations in the Age of AI with ServiceNow Chairman and CEO Bill McDermott
ServiceNow CEO Bill McDermott discusses his journey from entrepreneur to CEO and how he navigates leadership in the age of AI. He shares insights on scaling global organizations, hyper-growth, and staying customer-centric. The episode also…
- The Agentic Economy: How AI Agents Will Transform the Financial System with Circle Co-Founder and CEO Jeremy Allaire
This episode features Circle Co-Founder and CEO Jeremy Allaire discussing the agentic economy and how AI agents will transform the financial system. He explains the role of stablecoins like USDC and Circle’s Arc Blockchain in facilitating…
- AI for Atoms: How Periodic Labs is Revolutionizing Materials Engineering with Co-Founder Liam Fedus
Liam Fedus, co-founder of Periodic Labs, is interviewed on the No Priors podcast. He discusses applying AI to materials engineering, using language models as an orchestration layer for physical experiments, and the future of AGI and roboti…
- Andrej Karpathy on Code Agents, AutoResearch, and the Loopy Era of AI
On the No Priors podcast, Andrej Karpathy joins Sarah Guo to discuss AI agents, the future of engineering and education, and the AutoResearch project which focuses on autonomous AI research. They explore topics such as model capabilities,…
- From Coder to Manager: Navigating the Shift to Agentic Engineering with Notion Co-Founder Simon Last
Notion Co-Founder Simon Last discusses Notion's evolution to a platform for custom AI agents and the shift to agentic engineering. He also talks about the challenges of semantic indexing and retrieval, and the impact of coding agents on te…
- How Capital is Powering the AI Infrastructure Buildout with Magnetar Capital Managing Director Neil Tiwari
Neil Tiwari, Managing Director at Magnetar Capital, discusses how capital is powering the AI infrastructure buildout. He explains debt structures for financing GPU clusters and identifies bottlenecks like power distribution and energy stor…
- From SaaS to AI-First: How Companies Are Reshaping Innovation
This episode of No Priors discusses the evolving landscape of software and how AI is transforming the traditional SaaS model. The conversation covers new business strategies, how AI reshapes software development, and its impact on innovati…
- Rivian’s Roadmap to AI Architecture and Autonomy with Founder and CEO RJ Scaringe
Rivian CEO RJ Scaringe details the company's AI architecture and evolution in autonomous vehicle technology. He explains Rivian's move to a vertically integrated data stack and software-defined vehicle architecture. Scaringe also discusses…
- Introducing 4D Creation Open Beta: NPCs, 4D Worlds, and the Future of Gaming with Roblox CEO Dave Baszucki
Roblox CEO Dave Baszucki joins No Priors to discuss 4D creation, NPCs, and the future of gaming. He explains how Roblox uses AI and physics simulation to create immersive virtual experiences and leverages user data to train AI models for h…
- Why Cryopreservation is No Longer Science Fiction with Until Co-founder and CEO Laura Deming
Laura Deming, CEO and co-founder of Until, discusses reversible cryopreservation, addressing its scientific challenges and potential applications in medicine, such as revolutionizing organ transplantation. She explains how her company aims…
- No Priors Live: Building Durable Software in the AI Age with MongoDB President & CEO CJ Desai
In this episode, MongoDB President & CEO CJ Desai joins Sarah Guo to discuss building durable software in the AI age. They talk about why platforms are more durable than products, the slow adoption of AI in large companies, and debunking t…
- AI and the Future of Warfare with US Under Secretary of War Emil Michael
Emil Michael, US Under Secretary of War for Research and Engineering, joins Sarah Guo and Elad Gil to discuss the role of AI in the future of warfare, including the GenAI.mil platform and other critical technology priorities for national s…
- NVIDIA’s Jensen Huang on Reasoning Models, Robotics, and Refuting the “AI Bubble” Narrative
NVIDIA CEO Jensen Huang joins Sarah Guo and Elad Gil to discuss AI, robotics, and the "AI Bubble" narrative. He shares insights on AI's impact on jobs, labor shortages, and his 2026 outlook on US-China relations and open source.
- The 2026 AI Forecast: Foundation Models, IPOs, and Robotics with Sarah Guo and Elad Gil
Sarah Guo and Elad Gil forecast major AI trends for 2026, covering foundation models, robotics, and the return of tech IPOs. They also discuss AI adoption in various industries and consumer AI innovation challenges.
- The Future of Voice AI: Agents, Dubbing, and Real-Time Translation with ElevenLabs Co-Founder Mati Staniszewski
In this episode, ElevenLabs co-founder Mati Staniszewski discusses the future of voice AI, covering topics such as agents, dubbing, and real-time translation. He also explores the technical challenges of building foundational audio models…
- Scaling Legal AI and Building Next-Generation Law Firms with Harvey Co-Founder and President Gabe Pereyra
Gabe Pereyra, co-founder of Harvey, discusses how the company is scaling legal AI and transforming legal work for law firms. He explains how Harvey analyzes complex legal tasks and deploys AI agents for research and drafting, and the strat…
- Sunday Robotics: Scaling the Home Robot Revolution with Co-Founders Tony Zhao and Cheng Chi
Tony Zhao and Cheng Chi, co-founders of Sunday Robotics, discuss the state of AI robotics, challenges in developing their technology, and the impact of diffusion policy and imitation learning. They also talk about their 2026 in-home beta p…
- How AI Will Accelerate Breakthroughs in Biotechnology with Benchling CEO Sajith Wickramasekara
Sajith Wickramasekara, CEO of Benchling, joins the podcast to discuss how AI can accelerate breakthroughs in biotechnology. He explains how AI agents and simulation can help scientists with drug development and address challenges in the bi…
- Meet Snowflake Intelligence: A Personalized Enterprise Intelligence Agent with Sridhar Ramaswamy
Sridhar Ramaswamy, CEO of Snowflake, discusses the company's new AI agent platform, Snowflake Intelligence, and its implications for enterprise data management. He also covers Snowflake's pivot to an AI-first approach and strategic partner…
- The Best of 2025 (So Far) with Sarah Guo and Elad Gil
Sarah Guo and Elad Gil review their favorite No Priors conversations of 2025, featuring insights from various founders and scientists on recent AI advancements and their impact. The episode covers topics such as spatial intelligence, AI di…
- Reinventing the Developer Terminal with Warp Co-Founder and CEO Zach Lloyd
Zach Lloyd, CEO of Warp, discusses how reinventing the developer terminal can unlock AI agents for coding, debugging, and automating the development process. He talks about the evolution of software development and the future of AI in the…
- Unlocking the Road to Energy Abundance with Base Power CEO and Co-Founder Zach Dell
Zach Dell, CEO of Base Power, speaks with Elad Gil about energy abundance, the role of batteries in the grid, and regulatory challenges. They also discuss Base Power's mission to reduce electricity costs and its recent $1 billion fundraisi…
- Humans&: Bridging IQ and EQ in Machine Learning with Eric Zelikman
Eric Zelikman, founder of humans&, discusses his new venture which aims to integrate emotional intelligence (EQ) into machine learning models. He shares his insights on developing human-centric AI and fostering collaborative AI systems, mo…
- The Impact of AI, from Business Models to Cybersecurity, with Palo Alto Networks CEO Nikesh Arora
Nikesh Arora, CEO of Palo Alto Networks, discusses the impact of AI on business models, cybersecurity, and the future of search. He also shares his leadership philosophy and optimism about AI. The conversation covers topics from agentic AI…
- Reinventing K-12 Education Using AI with Alpha School Principal Joe Liemandt
Joe Liemandt, principal of Alpha School, discusses his vision for reinventing K-12 education using AI. He describes Alpha School's strategies, such as a two-hour academic day, the use of "Guides," and project-based workshops. The discussio…
- AI Agents Talking to AI Agents: Reinventing Commerce with Decagon CEO Jesse Zhang
Jesse Zhang, CEO of Decagon, discusses the role of AI agents in reinventing commerce and customer service. He shares insights into Decagon's growth, customer integration, and the future of agentic customer service.
- Jared Kushner: BrainCo, Affinity Partners, and the Geopolitics of AI
Jared Kushner joins Sarah Guo and Elad Gil to discuss his investment firm Affinity Partners, his time in government, and his new AI venture BrainCo. He covers Affinity Partners’ mission and strategy, leveraging government experience in bus…
- A New Operating System for Physicians with OpenEvidence Founder Daniel Nadler
OpenEvidence founder Daniel Nadler discusses with Sarah Guo and Elad Gil how his company is changing how doctors access critical information and how technology will reshape medicine and medical education. He also shares his philosophy on m…
- Reshaping America’s Economy for the Superintelligence Century with Jacob Helberg
Jacob Helberg joins Sarah Guo and Elad Gil to discuss how AI can reshape America's economy. Topics include AI's role in reshoring manufacturing, supply chain security, and transforming the US energy grid, as well as the CapEx revolution an…
- How Agentic AI is Transforming The Startup Landscape with Andrew Ng
Andrew Ng joins Sarah Guo and Elad Gil on the No Priors podcast to discuss how agentic AI is transforming the startup landscape. They explore the evolution of founder success, the value of small teams, and future AI capability growth. Ng a…
- Chips, Neoclouds, and the Quest for AI Dominance with SemiAnalysis Founder and CEO Dylan Patel
Dylan Patel, SemiAnalysis Founder and CEO, joins Sarah Guo to discuss AI infrastructure, including challenging Nvidia, the landscape of neoclouds, and bottlenecks for expanding AI. They also discuss predictions regarding OpenAI's open sour…
- The Shifting Value of Content in the AI Age with Cloudflare CEO Matthew Prince
Matthew Prince, Cloudflare CEO, joins Sarah Guo and Elad Gil on No Priors to discuss how AI is changing the internet and the value of content. He talks about Cloudflare's role in securing the internet and facilitating a new content marketp…
- America’s Plan to Dominate the Full AI Stack with Sriram Krishnan
Sriram Krishnan joins Elad Gil and Sarah Guo to discuss America’s AI Action Plan, an executive order outlining how the country can maintain AI supremacy. They explore the importance of winning the AI race, the core goals of the Action Plan…
- The Power of Quality Human Data with SurgeAI Founder and CEO Edwin Chen
Edwin Chen, CEO of SurgeAI, joins No Priors to discuss the significance of quality human data in the context of generative AI. He talks about SurgeAI's bootstrapping journey, scalable oversight for data quality, and their work on standardi…
- Asimov: Building An Omniscient RL Oracle with ReflectionAI’s Misha Laskin
Misha Laskin of ReflectionAI joins Sarah Guo on the No Priors podcast to introduce Asimov, a new code comprehension agent built on reinforcement learning. They discuss designing AI agents based on customer needs, solving scaling challenges…
- Why Platforms Win and Point Solutions Fail with Rippling CEO Parker Conrad
Parker Conrad, CEO of Rippling, shares insights on building successful platforms versus point solutions, drawing from his experience with Zenefits. He also discusses founder psychology, the impact of AI on software development, and the imp…
- Chai-2: The AI Model Accelerating Drug Discovery with Chai Discovery Co-Founders Jack Dent and Joshua Meier
Jack Dent and Joshua Meier, co-founders of Chai Discovery, discuss their Chai-2 AI model, which is designed to accelerate drug discovery by creating bespoke antibodies. They explain how the model works, its implications for the pharmaceuti…
- Meet AlphaEvolve: The Autonomous Agent That Discovers Algorithms Better Than Humans With Google DeepMind’s Pushmeet Kohli and Matej Balog
Pushmeet Kohli and Matej Balog from Google DeepMind discuss AlphaEvolve, an autonomous AI agent that finds new algorithms through evolutionary search. They explore how AlphaEvolve addresses matrix multiplication efficiency, its scaling cap…
- The Operating System for Self Driving Cars (and Tanks, and Trucks...) With Qasar Younis and Peter Ludwig of Applied Intuition
Qasar Younis and Peter Ludwig of Applied Intuition discuss the development of an operating system for autonomous vehicles, the potential for re-shoring manufacturing, and the impact on urban design. They also cover gauging safety in autono…
- Will we have Superintelligence by 2028? With Anthropic’s Ben Mann
Anthropic Co-Founder Ben Mann talks about the development of Claude 4, AI safety, and the future of AI models. He discusses economic Turing tests, RLAIF, and Anthropic’s Model Context Protocol, as well as the possibility of superintelligen…
- Teaching AI to Understand the Physical World, with Dr. Fei-Fei Li of World Labs
In this episode, Dr. Fei-Fei Li discusses teaching AI to understand the physical world, the challenges of 3D world modeling, and building exceptional teams. She shares her insights on the future of AI and robotics.
- AI Consolidation, Biotech Opportunities, and World Models with Sarah and Elad
This episode of No Priors features Sarah and Elad discussing AI market consolidation, opportunities in biotech, and the development of world models. They explore how AI's understanding of complex systems could change human discovery and pr…
- AI is Making Enterprise Search Relevant, with Arvind Jain of Glean
Arvind Jain, founder and CEO of Glean, joins No Priors to discuss how large language models are changing enterprise search. He talks about the challenges of building Glean and the future of AI-powered internal knowledge applications.
- Gaming as the Future of Education with Duolingo CEO Luis von Ahn
Duolingo CEO Luis von Ahn discusses how Duolingo uses game mechanics and AI to engage learners and personalize education. He also shares insights on Duolingo's brand, new courses, and the impact of AI on content creation.
- O3 and the Next Leap in Reasoning with OpenAI’s Eric Mitchell and Brandon McKinzie
Eric Mitchell and Brandon McKinzie from OpenAI discuss the O3 model, focusing on its unique reasoning capabilities, the role of reinforcement learning, and how tool use enhances interactions. The conversation also explores the future of hu…
- Inside Deep Research with Isa Fulford: Building the Future of AI Agents
Isa Fulford, a key figure in deep research, discusses the initiative's origins, the significance of human expert data, and the process of building capable AI agents. She also addresses the challenges of latency and compares deep research t…
- Predicting the Earth with Josh Goldman: How KoBold Uses AI to Find Critical Minerals
On this episode of No Priors, Josh Goldman, cofounder of KoBold Metals, explains how the company uses AI to discover critical minerals. He discusses KoBold's technical approach, how they validate hypotheses, and the scarcity of world-class…
- From Job Displacement to AI Trainers, Brendan Foody on Work in the AI Age
Brendan Foody, CEO and cofounder of Mercor, discusses the impact of AI on the labor market, including job displacement, the evolution of skill sets, and the future of hiring. The conversation covers evaluating talent with AI and the changi…