Liver Lineup: Innovations in Cholestatic Disease Management, With Kris Kowdley, MD
In this episode of Liver Lineup: Updates & Unfiltered Insights , host Nancy Reau, MD, sits down with Kris Kowdley, MD, to discuss evolving approaches in cholestatic liver disease, with a particular focus on primary biliary cholangitis (PBC). Key episode timestamps: 0:00:00 – Guest intro & evolution of PBC therapy 0:07:34 – Redefining biochemical response & earlier assessment 0:16:26 – OCA withdrawal & positioning PPARs/fibrates 0:22:16 – Diagnosing AMA‑negative PBC 0:25:58 – Genetic cholestasis panels & PFIC spectrum 0:29:45 – Symptom burden, pruritus, & IBAT inhibitors 0:35:17 – Bone health & closing remarks