a16z Podcast
Technology
About
Andreessen Horowitz on technology, business and culture.
Episodes
- Ben Horowitz on the Next Technology Era
David Ulevitch speaks with Ben Horowitz about what it means to lead the technology industry at scale, and the responsibilities that come with it. Following the firm’s largest-ever fundraise, they discuss how venture capital, technology, an…
- Crypto Fund 5: We Raised $2.2B. Here’s Why.
This episode discusses the launch of a16z crypto's fifth fund and the evolution of the crypto industry. It covers topics like stablecoins, onchain finance, and the overlap between crypto and AI.
- The New Space Race: NASA, Artemis, and the Race to the Moon
Morgan Brennan interviews NASA Administrator Jared Isaacman regarding the future of American space exploration, including the Artemis program, and the goal of returning to the moon. They discuss the challenges involved, the role of public-…
- Building Blackstone, Backing Costco, with Tony James
Tony James discusses his experiences building Blackstone, the evolution of private markets, and the importance of leadership and culture in scaling organizations. He also shares lessons from backing companies like Costco.
- Sarah Rogers: Free Speech, AI Diplomacy, and What America Owes Its Allies
Katherine Boyle and Sarah Rogers discuss the intersection of AI, free speech, and global information systems, examining how technological shifts have reshaped communication and power. They explore the role of public diplomacy in the digita…
- Balaji and Taylor Lorenz on AI and Media
This episode features Balaji Srinivasan and Taylor Lorenz discussing the impact of AI on media, trust, and online communication. They explore topics such as the breakdown of traditional information systems, the rise of AI-generated content…
- Workday’s Last Workday? AI and the Future of Enterprise Software
Elena Burger and Joe Schmidt discuss the future of enterprise software and AI, using Workday as a case study. They examine how platform shifts reshape categories, the potential for AI-native replacements, and how agents might change compan…
- The Shift in Global Drug Development
Theo Jaffee and Gabriel Dickinson speak with Cremieux about China’s rapid rise in global clinical trial output. They discuss the regulatory reforms that accelerated China’s progress and the surge in novel drug development.
- John and Patrick Collison on Stripe's Growth, Agent Commerce, and the Future of Software
John and Patrick Collison, cofounders of Stripe, discuss the company's growth, agent commerce, and the future of software economics. They explore how agent commerce and stablecoins might necessitate high-throughput blockchains and the shif…
- Ben Horowitz on Venture Capital and AI
Ben Horowitz and Anjney Midha discuss how venture capital changed from a relationship-driven business to a scalable system for backing new technology companies. They also cover network effects, firm design, leadership, culture, and the imp…
- AI Inside the Enterprise
Steven Sinofsky, Aaron Levie, and Martin Casado discuss the reality of AI inside enterprises. They cover why most AI initiatives fail in large organizations and how agents, infrastructure, and workflows are evolving.
- Martin Shkreli on AI, Pharma, and What Actually Matters
Erik Torenberg interviews Martin Shkreli. They discuss the AI landscape, the future of computing, "vibe coding," and the complexities of biotech and pharma industries.
- Balaji Srinivasan: Prove Correct, Not Just Go Direct
Erik Torenberg and Theo Jaffee speak with Balaji Srinivasan about AI's impact on media, trust, and information. They discuss how synthetic content affects systems like journalism and online communication, and the role of cryptography and o…
- Marc Andreessen: Monitoring the Situation and the Future of Media
Marc Andreessen, cofounder of a16z, discusses the launch of Monitoring the Situation (MTS), a new media network on X. He explores the spread of narratives and how internet-native media is impacting politics, culture, and attention.
- Rethinking Git for the Age of Coding Agents with GitHub Cofounder Scott Chacon
Matt Bornstein speaks with Scott Chacon, cofounder of GitHub and CEO of GitButler. They discuss why Git's user interface has barely changed since 2005 and how GitButler is rethinking version control for both humans and AI agents.
- Network Effects, AI Costs, and the Future of Consumer Investing with Anish Acharya on The Kevin Rose Show
This episode, originally aired on The Kevin Rose Show, features a discussion with Anish Acharya about AI's influence on consumer software, network effects, and the economics of inference. They also cover model pricing, the future of work,…
- The System Behind Self-Driving: Waymo’s Dmitri Dolgov
This episode features Waymo Co-CEO Dmitri Dolgov and John Collison discussing how self-driving technology works. They cover topics such as sensor fusion, simulation, and the impact of AI on decision-making, and differentiate full autonomy…
- Technology, Culture, and the Next AI Interface with signüll
This episode of the a16z Podcast features Erik Torenberg and Anish Acharya with guest signüll. They discuss technology's impact on culture and relationships, AI interfaces, and what consumer founders should focus on.
- Replit's CEO on Vibe Coding, Wealth Building, and What Most People Get Wrong About AI
Replit CEO Amjad Masad talks with Jack Neel about how AI simplifies software creation, Replit's success, and his perspective on AI as empowerment rather than a risk.
- Ben Horowitz on AI Infrastructure, Economics and The New Laws of Software
Ben Horowitz discusses how AI has changed software competition, the importance of crypto infrastructure in an AI-driven world, and the future of venture capital. This conversation was recorded live at the a16z Fintech Connect conference.
- Building Agents at Home: Parenting, Work, and Benevolent Neglect
Jesse Genet, a startup founder and mother of four, discusses building 11 AI agents to assist with tasks ranging from coding to curriculum planning and household management. She shares how this has impacted her life as a founder and a mothe…
- What Running Windows at Microsoft Taught Steven Sinofsky About Apple
Steven Sinofsky discusses Apple's 50th anniversary, the cultural differences between Apple and Microsoft, the impact of the MacBook Neo on Windows laptops, and where hardware and software design are headed.
- Who Controls AI Acceleration? Vitalik Buterin and Guillaume Verdon Debate
This episode features a debate between Vitalik Buterin, founder of Ethereum, and Guillaume Verdon, founder and CEO of Extropic. They discuss AI acceleration, concentrated power, and the roles of open source and decentralization in AI devel…
- The Agent Era: Building Software Beyond Chat with Box CEO Aaron Levie
This a16z Podcast episode features Box CEO Aaron Levie discussing the future of enterprise software in an "agent era." He talks with Erik Torenberg, Steve Sinofsky, and Martin Casado about agent success, abstraction layers, and data access…
- Balaji on Why AI Raises the Cost of Verification
Balaji Srinivasan and Erik Torenberg discuss how AI simultaneously reduces the cost of creation and increases the cost of verification. They explore what this dynamic means for the AI economy, including the shift towards "trusted tribe" mo…
- Peter Yang on Small Teams, Coding Agents, and Why Human Ambition Has No Ceiling
Peter Yang, creator and product lead at Roblox, discusses personal AI agents, coding agents, and the decreasing cost of building software. He explores the concept of radically small future companies, the evolving role of the IDE, and how h…
- Marc Andreessen on AI Winters and Agent Breakthroughs
Marc Andreessen joins swyx and Alessio Fanelli to discuss the history and future of artificial intelligence. Topics include AI scaling laws, coding agents, and the impact of human factors on AI development.
- Alex Blania on Proof of Human and Building World's Identity Network
Alex Blania, cofounder and CEO of Tools for Humanity, World, and cofounder of Merge Labs, discusses building a proof-of-human network with iris biometrics. The conversation covers the technical challenges and privacy architecture of World…
- What Happens When a Public Company Goes All In on AI
David Haber speaks with Owen Jennings about Block's restructuring around AI agents and tools. They discuss the execution of this restructuring and the development of AI-native products like Money Bot and Manager Bot.
- How Radiant and Heron Are Rethinking Power Generation and Delivery
This episode features a discussion with Doug Bernauer of Radiant and Drew Baglino of Heron about modernizing American energy infrastructure. Topics include portable micro nuclear reactors, solid state power electronics, and modular manufac…
- Marc Andreessen on Evaluating Founders and AI's Consumer Surplus
This episode features Marc Andreessen discussing his framework for evaluating founders, focusing on IQ, courage, and drive. He also shares insights on AI's consumer surplus, its impact on the tech industry, and why he believes the labor di…
- The SpaceX and Tesla Playbook for Hard Tech Startups
This episode features Erin Price-Wright, Chandler Luzsicza, and Turner Caldwell discussing their experiences building Starship and Tesla's lithium refinery, and how these lessons apply to their own startups. They cover topics such as decis…
- Security, Resilience, and the Future of Mobile Infrastructure
David Ulevitch speaks with Justin Fanelli, CTO of the Navy, and John Doyle, founder and CEO at Cape, about the Navy's approach to technology adoption and securing mobile infrastructure. They discuss the Salt Typhoon breach and how Cape bui…
- Submarines and the Future of Defense Manufacturing
This episode of the a16z Podcast features a discussion with David Ulevitch, Chris Power, and Vice Admiral Robert Gaucher. They discuss the state of America's submarine industrial base, the need for increased manufacturing capacity, and how…
- The Missing Power Layer of Modern Warfare
In this episode, Erin Price-Wright speaks with Adam Warmoth and Alex Miller about the power crisis in modern military operations and how commercial technology and procurement reform are addressing it.
- Why Every Satellite Needs Earth | Northwood CEO on a16z
Bridgit Mendler, CEO of Northwood, joins a16z to discuss the importance of ground infrastructure for satellites. They cover Northwood's work in connecting satellites to Earth and how modern ground networks can advance the space economy.
- Inside Palantir: Building Software That Matters with Shyam Sankar
Shyam Sankar, CTO of Palantir Technologies, discusses his new book "Mobilize," his military background, and the impact of AI on the SaaS market. He also shares insights on the distinction between alpha and beta software and his venture int…
- AI Just Gave You Superpowers — Now What?
This episode features a discussion with Christian Catalini and Eddy Lazzarin about a paper titled "Some Simple Economics of AGI." They explore the economic implications of artificial general intelligence, its impact on labor markets, and t…
- AI, Supply Chains, and the Future of Economic Power
This episode features Erik Torenberg and Jacob Helberg discussing AI, manufacturing, supply chains, and the geopolitics of technology. They explore the importance of hardware, industrial capacity, and secure supply chains for economic stre…
- What's Missing Between LLMs and AGI - Vishal Misra & Martin Casado
Vishal Misra explains his research on how LLMs function and update predictions. He clarifies why current LLMs are not conscious and what capabilities are necessary for artificial general intelligence (AGI), such as continued learning and u…
- AI Startups vs. Big Chatbots — With Olivia Moore
In this episode, Olivia Moore discusses competition between AI startups and large chatbots, negative American sentiment toward AI, and findings from giving LLMs personality tests. She also examines the divergence of ChatGPT, Claude, and Ge…
- Marc Andreessen on the Mindset of Great Founders — with David Senra
Marc Andreessen and David Senra discuss entrepreneurship and the mindset of successful founders. They explore patterns in great founders, their focus on building, and the impact of technology and entrepreneurship on the future.
- Emil Michael: Iran, Anthropic and the Future of AI at the Pentagon
In this episode, Emil Michael discusses his experience at the Pentagon, focusing on prioritizing applied AI and resolving issues with commercial AI contracts that posed risks to military operations. The conversation also touches on Iran an…
- Palantir CEO Alex Karp on the Zero-Sum AI Race
Palantir CEO Alex Karp discusses the role of technology in modern warfare, Silicon Valley's obligations to national defense, and America's competitive advantage in cultivating unconventional talent. This conversation was recorded at the a1…
- What It Takes to Clear a Million Crimes a Year with Flock Safety's CEO
This episode features Garrett Langley, CEO of Flock Safety, discussing the company's technology. He explains how Flock Safety, deployed in over 6,000 cities, aids in clearing over a million crimes annually through products like license pla…
- The Top 100 Gen AI Consumer Apps
Anish Acharya and Olivia Moore discuss the a16z Top 100 AI Apps report. They cover why ChatGPT is still significantly larger than Claude on the web, how major platforms are specializing for different users, and global AI adoption data.
- Andrew Huberman: Peptides, Sleep Tech, and the End of Obesity
On the a16z Podcast, Dr. Andrew Huberman and Daisy Wolf discuss the consumer health revolution, emerging peptide and GLP landscape, focus drugs, and neurotechnologies. They also cover how neurotechnologies could allow individuals to "write…
- Atlassian CEO on the SaaS Apocalypse, AI Agents & What Comes Next
Atlassian CEO Mike Cannon-Brookes joins Alex Rampell and Erik Torenberg to discuss the SaaS selloff and how Atlassian views AI-driven risks and the shift from records to processes. They also explore the design challenges of integrating AI…
- Ben Thompson: Anthropic, the Pentagon, and the Limits of Private Power
Ben Thompson, founder of Stratechery, discusses his essay "Anthropic and Alignment" and the intersection of AI power and state power. The conversation explores the standoff between Anthropic and the Department of War.
- Deploying AI in Healthcare
Nikhil Buduma and Julie Yoo discuss the deployment of AI in healthcare. They cover how AI is transforming clinical workflows, the challenges of building AI products, and the ROI of AI in healthcare, including its impact on EHR systems.